Mortality rate was High-dose pralidoxime for organophosphorus poisoning. All the patients were then shifted to the ICU for further management. Intern Med China ; However, because of low cost and easy availability, it has also become an agent of choice for self poisoning.

Clinical features of patients with acute organophosphate poisoning requiring intensive care. Abu Nadeem Department of Anaesthesiology, J. Written informed consent was obtained from all participants. Bikramjit Das Department of Anaesthesiology, J. Cholinesterase reactivators cannot pass through blood—brain barrier, so pralidoxime iodide combined with atropine is restricted in the treatment. Overall mortality rate was Neurotoxic effects of organophosphorus insecticides and intermediate syndrome.

J Coll Physicians Surg Pak.

In the present study, posioning incidence of poisoning was higher in males than in females. J Neurol Sci ; This case is inapplicable to poisons with a high lipid solubility or binding rate with proteins.

organophosphorus poisoning thesis

The treatment group comprised 34 patients, including organophoshporus male and 16 female patients. All the patients were then shifted to the ICU for further management.

National Poison Information Centre (24×7)

Published online Jun This article has been cited by other articles in PMC. The treatment group comprised 34 patients, including 18 male and 16 female patients. The routine use of specific antidote anticholinergic drug atropine can relieve the muscarinic symptoms of patients and resist central respiratory depression. Intermediate syndrome in organophosphorus poisoning: The average dose of PAM required per patient was Senanayake N, Karaliedde L.


The results of this study revealed the following: The authors have no conflicts of interest tuesis disclose. Initial management of all patients with pralidoxime PAM and atropine were done as per the recommended dosage schedule. However, a beneficial response has been reported even after 24 hours of exposure.

The control group comprised 34 patients, including 17 male and 17 female patients. Though each predictor age, lag time, severity of poisoning and duration of ventilation is associated with mortality, death due to OP poisoning results from overlapping contribution of these factors.

Thesis details | Ciências Farmacêuticas

Footnotes Source of Support: Among these 16 patients, 6 patients had moderate and 10 patients had severe poisoning. In order to improve the success rate of clinical organophoephorus, a retrospective analysis is made of clinical treatment approaches of 68 patients with severe and acute organophosphorus poisoning admitted by the hospital as well as their prognosis.

organophosphorus poisoning thesis

Opportunities for prevention and improved medical management. Williams and Wilkins; The age of these patients ranged within 19 to 66 years, with an average age of However, records of seven patients were incomplete and hence were excluded from the poisonning.


organophosphorus poisoning thesis

PAM, compound, thess regenerates and reactivates acetylcholinesterase from the OP-cholinesterase complex, is used as an antidote to treat OP poisoning. Correlation between lag period of starting of PAM and duration of mechanical ventilation. Clin Toxicol Phila ; Loisoning S, Muhammed G.

Our observation was similar to the previous studies that showed the highest incidence of OP poisoning in people aged between 21 and 39 years. This article has been cited by other articles in PMC.

Thesis details | Ciências Farmacêuticas

The curative effects in these 2 groups and the prognosis after rescue were compared. The recorded time interval between OP poisoning and starting of PAM lag time was significantly higher in those who died.

J Toxicol Clin Toxicol. The average dose of PAM required per patient was